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. 2000 Dec;9(4):190-4.
doi: 10.1097/00019606-200012000-00003.

Increased incidence of trisomy 8 in acute myeloid leukemia with skin infiltration (leukemia cutis)

F Sen  1 , X X Zhang, V G Prieto, C R Shea, M B Qumsiyeh
Affiliations

Increased incidence of trisomy 8 in acute myeloid leukemia with skin infiltration (leukemia cutis)

F Sen et al. Diagn Mol Pathol. 2000 Dec.

Abstract

Anecdotal literature reports and the authors' own observations suggest an association between chromosome 8 aneuploidy and leukemia cutis. The authors investigated this potential association by using fluorescence in situ hybridization (FISH) directly on skin infiltrates in a series of 11 patients with acute monocytic leukemia (AML). Seven of the 11 patients were aneuploid for chromosome 8 by FISH which was confirmed by dual color hybridization. Six of these seven patients were AML-M4 or M5 and one was M1. The majority of the cases with leukemia cutis expressed CD4 (90% of cases), CD14 (60%), and/or CD56 (50%) in bone marrow leukemic cells. The data show the utility of examination of skin infiltrates by FISH for the detection of trisomy 8 in leukemia cutis. They also suggest the importance of trisomy 8 as a factor in predisposition to skin infiltration in AML.

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