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. 2000 Dec 18;10(24):2713-7.
doi: 10.1016/s0960-894x(00)00556-4.

Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85

T Tselios  1 , I Daliani, S Deraos, S Thymianou, E Matsoukas, A Troganis, I Gerothanassis, A Mouzaki, T Mavromoustakos, L Probert, J Matsoukas
Affiliations

Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85

T Tselios et al. Bioorg Med Chem Lett. .

Abstract

In this report the rational design, synthesis and pharmacological properties of an amide-linked cyclic antagonist analogue of the guinea pig myelin basic protein epitope MBP(72-85) are described. Design of the potent cyclic analogue was based on 2D NOESY nuclear magnetic resonance and molecular dynamics studies carried out in the linear antagonist Ala81MBP(72-85). The cyclic antagonist completely prevented the induction of experimental allergic/autoimmune encephalomyelitis when coinjected with linear and cyclic agonist analogues MBP(72-85) and cyclo(2-9)MBP(72-85).

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