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Review
. 2001 Jan;107(1):7-11.
doi: 10.1172/JCI11830.

NF-kappaB: a key role in inflammatory diseases

P P Tak  1 , G S Firestein
Affiliations
Review

NF-kappaB: a key role in inflammatory diseases

P P Tak et al. J Clin Invest. 2001 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Activation of NF-κB in murine CIA. Mice were immunized with type II collagen on days 0 and 20 and boosted with lipopolysaccharide on day 28. Electromobility shift assays were performed on nuclear extracts of ankle joints at various time points during the evolution of disease. The right side of the gel shows NF-κB binding to labeled consensus NF-κB oligonucleotide, while the left side shows lack of binding to a mutant NF-κB oligonucleotide. Note that NF-κB binding activity was observed as early as 10 days after immunization, even though clinical arthritis was not observed until approximately day 30. Con, positive control.
See this image and copyright information in PMC

References

    1. Baldwin AS., Jr The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:649–683. - PubMed
    1. Chen F, Castranova V, Shi X, Demers LM. New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem. 1999;45:7–17. - PubMed
    1. Franzoso G, et al. Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev. 1997;11:3482–3496. - PMC - PubMed
    1. Vincenti MP, Coon CI, Brinckerhoff CE. Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts. Arthritis Rheum. 1998;41:1987–1994. - PubMed
    1. Miyazawa K, Mori A, Yamamoto K, Okudaira H. Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: spontaneous activation of NF-kappa B and CBF1. Am J Pathol. 1998;152:793–803. - PMC - PubMed