Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. I. The natural history: a histologic and immunohistologic study at the light microscopic and the ultrastructural level
- PMID: 1113514
Item in Clipboard
Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. I. The natural history: a histologic and immunohistologic study at the light microscopic and the ultrastructural level
Lab Invest.
1975 Feb.
Abstract
A new form of experimental immune complex glomerulonephritis is described which is induced by one single injection of heterologous antibody directed against antigens present in the brush border of the proximal tubules of the rat kidney. In this model, antigen-antibody complexes are deposited as early as 3 hours after injection of the heterologous antiserum. The first localization of these complexes is seen in the dense layer of the glomerular basement membrane. Later, they move up to the lamina rara externa and stay there for at least 3 months. This model is easily reproducible and offers possibilities for studying the effects of medication on the deposition of immune complexes.
Similar articles
-
Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. II. Influence of medication with prednisone and azathioprine: a histologic and immunohistologic study at the light microscopic and the ultrastructural level.Lab Invest. 1975 Feb;32(2):243-50. Lab Invest. 1975. PMID: 1089843
-
Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. IV. Investigations into the pathogenesis of the model.Lab Invest. 1978 Apr;38(4):496-501. Lab Invest. 1978. PMID: 147960
-
Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. V. Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis.Lab Invest. 1978 Apr;38(4):502-10. Lab Invest. 1978. PMID: 147961
-
[Immumologic aspects of Mazugi nephritis (review)].Patol Fiziol Eksp Ter. 1977 Mar-Apr;(2):85-9. Patol Fiziol Eksp Ter. 1977. PMID: 70014 Review. Russian. No abstract available.
-
The influence of antiglobulins in immunologic disease with specific reference to glomerulonephritis.Perspect Nephrol Hypertens. 1976;3:13-20. Perspect Nephrol Hypertens. 1976. PMID: 55998 Review. No abstract available.
Cited by
-
The detection and characterization of renal brush border antigen (gp108) in various rat tissues.Clin Exp Immunol. 1987 Jan;67(1):135-41. Clin Exp Immunol. 1987. PMID: 3304735 Free PMC article.
-
The specificity of nephritogenic antibodies. V. Glomerular localization of anti-GP 330 and anti-GP 90 antibodies present in passive Heymann serum.Br J Exp Pathol. 1988 Dec;69(6):855-64. Br J Exp Pathol. 1988. PMID: 3064801 Free PMC article.
-
Autoimmunity and glomerulonephritis.Postgrad Med J. 1992 Apr;68(798):242-50. doi: 10.1136/pgmj.68.798.242. Postgrad Med J. 1992. PMID: 1409187 Free PMC article. Review.
-
Antigenic targets in membranous glomerulonephritis.Springer Semin Immunopathol. 1987;9(4):341-58. doi: 10.1007/BF00197213. Springer Semin Immunopathol. 1987. PMID: 2963396 Review. No abstract available.
-
Proteinuria induced by anti-dipeptidyl peptidase IV (gp108); role of circulating and glomerular antigen.Clin Exp Immunol. 1994 Feb;95(2):327-32. doi: 10.1111/j.1365-2249.1994.tb06532.x. Clin Exp Immunol. 1994. PMID: 7905795 Free PMC article.