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Comment
. 2001 Jan;7(1):17-8.
doi: 10.1038/83289.

Is tissue plasminogen activator a threat to neurons?

S F Traynelis  1 , S A Lipton
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Comment

Is tissue plasminogen activator a threat to neurons?

S F Traynelis et al. Nat Med. 2001 Jan.

Abstract

The clot-busting drug tissue plasminogen activator (tPA) is currently the only FDA-approved therapy for acute stroke. However, increasing evidence suggests that tPA can also contribute to excitotoxic neuronal damage in animal models of stroke.

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