Wnt signaling: an embarrassment of receptors
- PMID: 11137030
- DOI: 10.1016/s0960-9822(00)00852-6
Wnt signaling: an embarrassment of receptors
Abstract
Recent genetic studies in Drosophila and mouse have uncovered a new aspect of the Wnt signal transduction machinery. Mutations disrupting LDL-receptor related proteins produce loss-of-function Wnt phenotypes, suggesting that these cell surface molecules may represent essential co-receptors for Wnt ligands.
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