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Clinical Trial
. 2000 Dec 8;19(9-10):1232-8.
doi: 10.1016/s0264-410x(00)00241-3.

A randomised, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants

M English  1 , J M MacLennan, J M Bowen-Morris, J Deeks, M Boardman, K Brown, S Smith, J Buttery, J Clarke, S Quataert, S Lockhart, E R Moxon
Affiliations
Clinical Trial

A randomised, double-blind, controlled trial of the immunogenicity and tolerability of a meningococcal group C conjugate vaccine in young British infants

M English et al. Vaccine. .

Abstract

A double-blind, randomised, controlled trial was conducted in 248 British infants to assess the immunogenicity and tolerability of three doses of a meningococcal group C/CRM (197) conjugate vaccine (Lederle Laboratories, USA) given at 2, 3 and 4 months. Control children received three doses of Hepatitis B vaccine (Engerix B(R); SmithKline Beecham). At 5 months of age, 100% of children receiving the conjugate vaccine had specific immunoglobulin G concentrations >2.0 microg/ml (n=116) compared with only 4% of control children (n=121). Those receiving the conjugate also had 2.5- and 1.6-fold higher geometric mean concentrations of PRP and diphtheria antibodies, respectively. The vaccine was well tolerated.

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