Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2001 Jan;157(1):445-54.
doi: 10.1093/genetics/157.1.445.

Mapping epistatic quantitative trait loci with one-dimensional genome searches

Affiliations
Comparative Study

Mapping epistatic quantitative trait loci with one-dimensional genome searches

J L Jannink et al. Genetics. 2001 Jan.

Abstract

The discovery of epistatically interacting QTL is hampered by the intractability and low power to detect QTL in multidimensional genome searches. We describe a new method that maps epistatic QTL by identifying loci of high QTL by genetic background interaction. This approach allows detection of QTL involved not only in pairwise but also higher-order interaction, and does so with one-dimensional genome searches. The approach requires large populations derived from multiple related inbred-line crosses as is more typically available for plants. Using maximum likelihood, the method contrasts models in which QTL allelic values are either nested within, or fixed over, populations. We apply the method to simulated doubled-haploid populations derived from a diallel among three inbred parents and illustrate the power of the method to detect QTL of different effect size and different levels of QTL by genetic background interaction. Further, we show how the method can be used in conjunction with standard two-locus QTL detection models that use two-dimensional genome searches and find that the method may double the power to detect first-order epistasis.

PubMed Disclaimer

References

    1. Genetics. 1995 Sep;141(1):333-46 - PubMed
    1. Genetics. 1994 Nov;138(3):871-81 - PubMed
    1. J Hered. 1988 Jul-Aug;79(4):225-38 - PubMed
    1. Genetics. 1992 Nov;132(3):823-39 - PubMed
    1. Genetics. 1989 Jan;121(1):185-99 - PubMed

Publication types