Review
doi: 10.1111/j.1753-4887.2000.tb01833.x.
The oxidation of 9-cis-retinol: a possible synthesis pathway for 9-cis-retinoic acid
Affiliations
- PMID: 11140907
- DOI: 10.1111/j.1753-4887.2000.tb01833.x
Item in Clipboard
Review
The oxidation of 9-cis-retinol: a possible synthesis pathway for 9-cis-retinoic acid
Nutr Rev.
2000 Nov.
Abstract
A short-chain alcohol dehydrogenase has been discovered that oxidizes 9-cis- and 11-cis-retinol to their corresponding aldehydes. The gene for this enzyme was sequenced and appears to be expressed with highest efficiency in the retinal pigment epithelium of the eye, as well as in human liver and mammary gland and in mouse liver and kidney. Because 9-cis-retinol occurs in liver, it may be a precursor of 9-cis-retinoic acid.
Similar articles
-
The visual cycle retinol dehydrogenase: possible involvement in the 9-cis retinoic acid biosynthetic pathway.FEBS Lett. 1998 May 29;428(3):135-40. doi: 10.1016/s0014-5793(98)00473-6. FEBS Lett. 1998. PMID: 9654122
-
Identification and characterization of a stereospecific human enzyme that catalyzes 9-cis-retinol oxidation. A possible role in 9-cis-retinoic acid formation.J Biol Chem. 1997 May 2;272(18):11744-9. doi: 10.1074/jbc.272.18.11744. J Biol Chem. 1997. PMID: 9115228
-
Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus.J Biol Chem. 2001 Aug 31;276(35):32456-65. doi: 10.1074/jbc.M104949200. Epub 2001 Jun 20. J Biol Chem. 2001. PMID: 11418621 Free PMC article.
-
Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signaling by activation of retinoic acid synthesis.Biochemistry. 1996 Sep 24;35(38):12221-7. doi: 10.1021/bi961176+. Biochemistry. 1996. PMID: 8823154 Review.
-
Retinoic acid homeostasis: retinoic acid regulates liver retinol esterification as well as its own catabolic oxidation in liver.Nutr Rev. 2001 Dec;59(12):391-4. doi: 10.1111/j.1753-4887.2001.tb06968.x. Nutr Rev. 2001. PMID: 11766909 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
