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. 2001 Jan 5;291(5501):134-7.
doi: 10.1126/science.291.5501.134.

Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors

S T Davis  1 , B G Benson, H N Bramson, D E Chapman, S H Dickerson, K M Dold, D J Eberwein, M Edelstein, S V Frye, R T Gampe Jr, R J Griffin, P A Harris, A M Hassell, W D Holmes, R N Hunter, V B Knick, K Lackey, B Lovejoy, M J Luzzio, D Murray, P Parker, W J Rocque, L Shewchuk, J M Veal, D H Walker, L F Kuyper
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Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors

S T Davis et al. Science. .

Retraction in

  • Retraction.
    Davis ST, Benson BG, Bramson HN, Chapman DE, Dickerson SH, Dold KM, Eberwein DJ, Edelstein M, Frye SV, Gampe RT Jr, Grifffen RJ, Harris PA, Hassell AM, Holmes WD, Hunter RN, Knick VB, Lackey K, Lovejoy B, Luzzio MJ, Murray D, Parker P, Rocque WJ, Shewchuk-Chapman L, Veal JM, Walker DH, Kuyper LF. Davis ST, et al. Science. 2002 Dec 20;298(5602):2327. doi: 10.1126/science.298.5602.2327b. Science. 2002. PMID: 12526115 No abstract available.

Abstract

Most traditional cytotoxic anticancer agents ablate the rapidly dividing epithelium of the hair follicle and induce alopecia (hair loss). Inhibition of cyclin-dependent kinase 2 (CDK2), a positive regulator of eukaryotic cell cycle progression, may represent a therapeutic strategy for prevention of chemotherapy-induced alopecia (CIA) by arresting the cell cycle and reducing the sensitivity of the epithelium to many cell cycle-active antitumor agents. Potent small-molecule inhibitors of CDK2 were developed using structure-based methods. Topical application of these compounds in a neonatal rat model of CIA reduced hair loss at the site of application in 33 to 50% of the animals. Thus, inhibition of CDK2 represents a potentially useful approach for the prevention of CIA in cancer patients.

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