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. 1975 Mar 7;187(4179):850-3.
doi: 10.1126/science.1114332.

Mapping of functional neural pathways by autoradiographic survey of local metabolic rate with (14C)deoxyglucose

C Kennedy, M H Des Rosiers, J W Jehle, M Reivich, F Sharpe, L Sokoloff

Mapping of functional neural pathways by autoradiographic survey of local metabolic rate with (14C)deoxyglucose

C Kennedy et al. Science. .

Abstract

An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido(3,4-b)indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vitro nor in vivo formation of these compounds by human tissues has been described.

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