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Review
. 2001 Jan;11(1):30-38.
doi: 10.1016/s0962-8924(00)01871-7.

Surfing pathogens and the lessons learned for actin polymerization

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Review

Surfing pathogens and the lessons learned for actin polymerization

F Frischknecht et al. Trends Cell Biol. 2001 Jan.

Abstract

A number of unrelated bacterial species as well as vaccinia virus (ab)use the process of actin polymerization to facilitate and enhance their infection cycle. Studies into the mechanism by which these pathogens hijack and control the actin cytoskeleton have provided many interesting insights into the regulation of actin polymerization in migrating cells. This review focuses on what we have learnt from the actin-based motilities of Listeria, Shigella and vaccinia and discusses what we would still like to learn from our nasty friends, including enteropathogenic Escherichia coli and Rickettsia

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