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Review
. 2001 Jan;3(1):E12-4.
doi: 10.1038/35050642.

Together until separin do us part

A Amon  1
Affiliations
Review

Together until separin do us part

A Amon. Nat Cell Biol. 2001 Jan.

Abstract

Loss of sister-chromatid cohesion triggers chromosome segregation. Several recent reports show that the protease Esp1 cleaves the cohesin subunit Scc1/Mcd1 to induce sister-chromatid segregation in yeast and vertebrates. This finding indicates that cohesin cleavage may control sister-chromatid separation in all vertebrates.

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