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Comparative Study
. 2001 Jan;39(1):92-9.
doi: 10.1002/1097-0274(200101)39:1<92::aid-ajim9>3.0.co;2-p.

Occupational exposure to pesticides and pancreatic cancer

B T Ji  1 , D T Silverman, P A Stewart, A Blair, G M Swanson, D Baris, R S Greenberg, R B Hayes, L M Brown, K D Lillemoe, J B Schoenberg, L M Pottern, A G Schwartz, R N Hoover
Affiliations
Comparative Study

Occupational exposure to pesticides and pancreatic cancer

B T Ji et al. Am J Ind Med. 2001 Jan.

Erratum in

  • Am J Ind Med 2001 Aug;40(2):225-6

Abstract

Background: An increased risk of exposure to pesticides for pancreatic cancer has been suggested in a number of epidemiologic studies.

Methods: Cases (N = 484), aged 30-79 years, were diagnosed in 1986-1989. Controls (N = 2,095) were a random sample of the general population. Information on usual occupation and potential confounding factors was obtained. A job-exposure matrix (JEM) approach was used to estimate the level of occupational exposure to pesticides.

Results: A significant trend in risk with increasing exposure level of pesticides was observed, with ORs of 1.3 and 1.4 for low and moderate/high exposure levels, respectively. Excess risks were found for occupational exposure to fungicides (OR = 1.5) and herbicides (OR = 1.6) in the moderate/high level after adjustment for potential confounding factors. An increased risk for insecticide exposure was disappeared after adjustment for fungicide and herbicide exposures. Results of our occupation-based analysis were consistent with those from the JEM-based analysis.

Conclusions: Our results suggest that pesticides may increase risk of pancreatic cancer, and indicate the need for investigations that can evaluate risk by specific chemical exposures. Published 2001 Wiley-Liss, Inc.

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