Capsulotomy

Abstract

Research is continually seeking to better describe the relationship between pseudophakic capsular opacification and underlying cell biology, surgical technique, and intra-ocular lens biomaterial and design. Outcomes are reviewed from prospective, randomized studies that investigate the importance of capsulorhexis size, pharmacological treatment, and lens material in influencing capsular opacification and the need for capsulotomy. The results of several studies support the role of lens edge profile in inhibiting lens epithelial cell migration. A large post-mortem study also examines how lens type may affect anterior capsular opacification formation. Of particular interest is a histological report that sheds additional light on understanding cellular processes in posterior capsu-lar opacification.