Synthesis and initial structure--activity relationships of modified salicylihalamides

Abstract

[reaction:see text] The first stereoselective total synthesis of the potent antitumor compound (-)-salicylihalamide A is presented. The practicality of our approach provides for high material throughput and is highlighted by the rapid construction of a variety of modified congeners. Initial structure-activity relationships are derived from growth inhibition experiments with a human melanoma cancer cell line.