doi: 10.1034/j.1399-302x.2000.150511.x.
Genetic transformation in Streptococcus mutans requires a peptide secretion-like apparatus
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- PMID: 11154426
- DOI: 10.1034/j.1399-302x.2000.150511.x
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Genetic transformation in Streptococcus mutans requires a peptide secretion-like apparatus
Oral Microbiol Immunol.
2000 Oct.
Abstract
Competence for genetic transformation in Streptococcus pneumoniae and Streptococcus gordonii involves the ComAB secretion apparatus, which is thought to export the competence-stimulating peptide. Homologous secretory systems are also used for the export of certain bacteriocins and bacteriocin-like peptides. In this study, a similar secretory apparatus was found in the Streptococcus mutans genome, and its role in transformation was investigated. Gene inactivation resulted in a mutant deficient in transformability. We suggest that secretion of a peptide, possibly the competence-stimulating peptide itself, is involved in competence induction also in S. mutans.
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