This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Review

. 2001 Jan 30;98(3):790-2.

doi: 10.1073/pnas.98.3.790.

Polycystic kidney disease: In danger of being X-rated?

J J Grantham¹, J P Calvet

Affiliations

Affiliation

¹ The Kidney Institute, and Departments of Medicine, and Biochemistry and Molecular Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. jgrantha@kumc.edu

PMID: 11158545
PMCID: PMC33367
DOI: 10.1073/pnas.98.3.790

Review

Polycystic kidney disease: In danger of being X-rated?

J J Grantham et al. Proc Natl Acad Sci U S A. 2001.

. 2001 Jan 30;98(3):790-2.

doi: 10.1073/pnas.98.3.790.

Authors

J J Grantham¹, J P Calvet

Affiliation

¹ The Kidney Institute, and Departments of Medicine, and Biochemistry and Molecular Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. jgrantha@kumc.edu

PMID: 11158545
PMCID: PMC33367
DOI: 10.1073/pnas.98.3.790

No abstract available

PubMed Disclaimer

Figures

Figure 1
Gross pathology of polycystic kidney. Closeup of surface at autopsy. Image provided by Dr. Edwin P. Ewing, Center for Disease Control and Prevention (1972).

See this image and copyright information in PMC

Comment on

Extrafloral nectar production of the ant-associated plant, Macaranga tanarius, is an induced, indirect, defensive response elicited by jasmonic acid.
Heil M, Koch T, Hilpert A, Fiala B, Boland W, Linsenmair K. Heil M, et al. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1083-8. doi: 10.1073/pnas.98.3.1083. Epub 2001 Jan 16. Proc Natl Acad Sci U S A. 2001. PMID: 11158598 Free PMC article.
Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel.
González-Perrett S, Kim K, Ibarra C, Damiano AE, Zotta E, Batelli M, Harris PC, Reisin IL, Arnaout MA, Cantiello HF. González-Perrett S, et al. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1182-7. doi: 10.1073/pnas.98.3.1182. Proc Natl Acad Sci U S A. 2001. PMID: 11252306 Free PMC article.

Similar articles

Transepithelial chloride secretion and cystogenesis in autosomal dominant polycystic kidney disease.
Persu A, Devuyst O. Persu A, et al. Nephrol Dial Transplant. 2000 Jun;15(6):747-50. doi: 10.1093/ndt/15.6.747. Nephrol Dial Transplant. 2000. PMID: 10831619 Review. No abstract available.
The pathogenesis of autosomal dominant polycystic kidney disease: an update.
Somlo S, Markowitz GS. Somlo S, et al. Curr Opin Nephrol Hypertens. 2000 Jul;9(4):385-94. doi: 10.1097/00041552-200007000-00010. Curr Opin Nephrol Hypertens. 2000. PMID: 10926175 Review.
Molecular complexes formed with polycystins.
Lakkis M, Zhou J. Lakkis M, et al. Nephron Exp Nephrol. 2003 Jan;93(1):e3-8. doi: 10.1159/000066648. Nephron Exp Nephrol. 2003. PMID: 12411743 Review.
Autosomal dominant polycystic kidney disease: modifier genes and endothelial dysfunction.
Devuyst O, Persu A, Vo-Cong MT. Devuyst O, et al. Nephrol Dial Transplant. 2003 Nov;18(11):2211-5. doi: 10.1093/ndt/gfg351. Nephrol Dial Transplant. 2003. PMID: 14551343 Review. No abstract available.
Ciliary function of polycystins: a new model for cystogenesis.
Joly D, Hummel A, Ruello A, Knebelmann B. Joly D, et al. Nephrol Dial Transplant. 2003 Sep;18(9):1689-92. doi: 10.1093/ndt/gfg256. Nephrol Dial Transplant. 2003. PMID: 12937209 No abstract available.

See all similar articles

Cited by

G-quadruplex stabilization provokes DNA breaks in human PKD1, revealing a second hit mechanism for ADPKD.
Parsons AM, Byrne S, Kooistra J, Dewey J, Zebolsky AL, Alvarado G, Bouma GJ, Vanden Heuvel GB, Larson ED. Parsons AM, et al. Nat Commun. 2025 Jan 2;16(1):121. doi: 10.1038/s41467-024-55684-y. Nat Commun. 2025. PMID: 39747084 Free PMC article.
Novel role of ouabain as a cystogenic factor in autosomal dominant polycystic kidney disease.
Blanco G, Wallace DP. Blanco G, et al. Am J Physiol Renal Physiol. 2013 Sep 15;305(6):F797-812. doi: 10.1152/ajprenal.00248.2013. Epub 2013 Jun 12. Am J Physiol Renal Physiol. 2013. PMID: 23761677 Free PMC article. Review.
On the Many Actions of Ouabain: Pro-Cystogenic Effects in Autosomal Dominant Polycystic Kidney Disease.
Venugopal J, Blanco G. Venugopal J, et al. Molecules. 2017 May 3;22(5):729. doi: 10.3390/molecules22050729. Molecules. 2017. PMID: 28467389 Free PMC article. Review.
Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing.
Sazani P, Kole R. Sazani P, et al. J Clin Invest. 2003 Aug;112(4):481-6. doi: 10.1172/JCI19547. J Clin Invest. 2003. PMID: 12925686 Free PMC article. Review.
ADPKD: molecular characterization and quest for treatment.
Horie S. Horie S. Clin Exp Nephrol. 2005 Dec;9(4):282-291. doi: 10.1007/s10157-005-0367-6. Clin Exp Nephrol. 2005. PMID: 16362154 Review.

References

1. Gonzalez-Perret S, Kim K, Ibarra C, Damiano A E, Zotta E, Batelli M, Harris P C, Reisin I L, Arnaout M A, Cantiello H F. Proc Natl Acad Sci USA. 2001;98:1182–1187. . (First Published December 26, 2000; 10.1073/pnas.021456598) - PMC - PubMed
1. Schwiebert E M, Benos D J, Egan M E, Stutts M J, Guggino W B. Physiol Rev. 1999;79:S145–S166. - PubMed
1. Grantham J J. J Am Soc Nephrol. 1993;3:1841–1857. - PubMed
1. Borland R M, Biggers J D, Lechene C P. J Reprod Fertil. 1977;51:131–135. - PubMed
1. Watson A J. Mol Reprod Dev. 1992;33:492–504. - PubMed

Publication types

Actions
Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources