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Comparative Study
. 2001 Jan;107(2):153-4.
doi: 10.1172/JCI11998.

Sarcoglycan, the heart, and skeletal muscles: new treatment, old drug?

J A Towbin  1 , N E Bowles
Affiliations
Comparative Study

Sarcoglycan, the heart, and skeletal muscles: new treatment, old drug?

J A Towbin et al. J Clin Invest. 2001 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Proteins of the sarcomere, cytoskeleton, sarcolemma, and ECM of muscle, which are connected. Mutations in δ-sarcoglycan, dystrophin, actin, desmin, and lamin A/C are known to cause DCM. All of these genes also cause forms of skeletal myopathy when mutated. Mutations in any of the genes illustrated could potentially cause DCM and/or skeletal myopathy, forming the basis of the “final common pathway.” Signaling pathways (such as nNos) interacting with these proteins are likely to modify the phenotype.
See this image and copyright information in PMC

Comment on

References

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