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Review
. 2001 Feb;107(3):241-6.
doi: 10.1172/JCI11991.

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB

A S Baldwin  1
Affiliations
Review

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB

A S Baldwin. J Clin Invest. 2001 Feb.
No abstract available

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Figures

Figure 1
Figure 1
Induction of NF-κB by TNF or other stimuli leads to the transcriptional activation of genes that suppress apoptosis. The proteins encoded by the genes function at different levels in the caspase cascade to block apoptosis.
Figure 2
Figure 2
Roles of NF-κB in oncogenesis and in cancer chemo- and radioresistance. Activation of NF-κB blocks apoptosis, induces cell proliferation, potentially blocks differentiation, and promotes metastasis.
See this image and copyright information in PMC

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