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Review
. 2001 Feb;11(1):27-34.
doi: 10.1016/s0959-437x(00)00152-0.

The von Hippel-Lindau tumor suppressor protein

M Ivan  1 , W G Kaelin Jr
Affiliations
Review

The von Hippel-Lindau tumor suppressor protein

M Ivan et al. Curr Opin Genet Dev. 2001 Feb.

Abstract

The von Hippel-Lindau tumor suppressor protein (pVHL) has been shown to bind directly to the alpha subunits of the heterodimeric transcription factor HIF (hypoxia inducible factor). pVHL directs the polyubiquitination and, hence, destruction of HIF in the presence of oxygen. Loss of pVHL function leads to deregulation of HIF target genes, which play critical roles in angiogenesis.

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