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. 2001 Feb 1;213(1-2):25-9.
doi: 10.1016/s0378-5173(00)00617-7.

Solubilization of rapamycin

P Simamora  1 , J M Alvarez, S H Yalkowsky
Affiliations

Solubilization of rapamycin

P Simamora et al. Int J Pharm. .

Abstract

The solubilization of rapamycin, a poorly water soluble investigational immunosuppressive drug, by facilitated hydrotropy is presented. Partially water-miscible aromatic solutes (such as benzyl alcohol, benzoate, or benzoic acid) can be solubilized by water-miscible cosolvents, such as ethanol and propylene glycol. Once solubilized, the partially miscible aromatic solute becomes a solubilizing agent. This technique yielded a dramatic (>1000-fold) increase in the aqueous solubility of rapamycin.

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