Review
doi: 10.1016/s0165-6147(00)01602-3.
The ligand that came from within
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- PMID: 11165666
- DOI: 10.1016/s0165-6147(00)01602-3
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Review
The ligand that came from within
Trends Pharmacol Sci.
2001 Jan.
Free article
Abstract
Recent evidence suggests that the endogenous activators of neuronal vanilloid (capsaicin) receptors should be sought inside, not outside, the neuron. 12-Lipoxygenase metabolites of arachidonic acid, produced by pain-inducing mediators such as bradykinin, might trigger vanilloid receptor activation by interacting with an intracellular site on the receptor. Are these lipid-like second messengers the long-sought endogenous vanilloids?
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