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. 2001 Mar;40(3):457-9.
doi: 10.1016/s0028-3908(00)00178-7.

Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat

R E Brown  1 , O Sergeeva, K S Eriksson, H L Haas
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Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat

R E Brown et al. Neuropharmacology. 2001 Mar.

Abstract

Orexin A (10-300 nM) strongly excited dorsal raphe serotonergic neurons maintained in vitro. The depolarization persisted in the presence of tetrodotoxin (TTX, 0.5 microM) and was associated with an increase in input resistance. These results have relevance in the context of food intake regulation and the disease, narcolepsy.

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