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Review
. 2001 Feb;26(2):124-30.
doi: 10.1016/s0968-0004(00)01737-0.

Ribosome fidelity: tRNA discrimination, proofreading and induced fit

M V Rodnina  1 , W Wintermeyer
Affiliations
Review

Ribosome fidelity: tRNA discrimination, proofreading and induced fit

M V Rodnina et al. Trends Biochem Sci. 2001 Feb.

Abstract

The ribosome selects aminoacyl-tRNAs with high fidelity. Kinetic studies reveal that codon-anticodon recognition both stabilizes aminoacyl-tRNA binding on the ribosome and accelerates reactions of the productive pathway, indicating an important contribution of induced fit to substrate selection. Similar mechanisms are used by other template-programmed enzymes, such as DNA and RNA polymerases.

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