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Review
. 2001 Jan;51(1):13-25.
doi: 10.1046/j.1365-2125.2001.01294.x.

Drug treatment of obesity: from past failures to future successes?

P Collins  1 , G Williams
Affiliations
Review

Drug treatment of obesity: from past failures to future successes?

P Collins et al. Br J Clin Pharmacol. 2001 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Diagrammatic representation of the effects of leptin in energy homeostasis.
Figure 2
Figure 2
Hypothetical dose-response curves for the anti-obesity action of leptin. In both men and rodents, the total absence of leptin causes hyperphagia and early-onset morbid obesity, proving that leptin is involved in regulating energy balance. In rodents, food intake and body weight fall as plasma leptin levels are increased through the physiological and into the pharmacological range. The shape of the dose-response curve in man is unknown, but leptin levels in the physiological and pharmacological range do not appear to decrease fat mass as powerfully as in rodents. This blunting of leptin action could be due to physiological ‘leptin resistance’ or the overwhelming effect of psychosocial factors in human eating behaviour.
Figure 3
Figure 3
Diagram showing binding of [125I]NDP-MSH in the rat hypothalamus. Binding is most intense at the hypothalamic ventromedial (VMH) and arcuate nuclei (ARC) and the median eminence (ME). With lower levels in the medial habenulla (MHb) These areas are known to be important in the control of food intake.
Figure 4
Figure 4
Immunohistochemical labelling (blue staining) of Orexin-A (upper panel) and MCH (lower panel) in the hypothalamus of rats made hypoglycaemic with insulin. 3V=3rd ventricle; f=fornix; mt=mammillothalamic tract.
See this image and copyright information in PMC

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