doi: 10.1016/s0021-9673(00)83807-8.
Determination of carbamazepine and its epoxide metabolite in plasma by high-speed liquid chromatography
- PMID: 1117034
- DOI: 10.1016/s0021-9673(00)83807-8
Item in Clipboard
Determination of carbamazepine and its epoxide metabolite in plasma by high-speed liquid chromatography
J Chromatogr.
.
Abstract
A liquid-chromatographic method for the simultaneous determination of carbamazepine and its active metabolite (carbamazepine 10,11-epoxide) in plasma has been developed. The two compounds were identified in plasma by mass spectrometry. The lower limit of sensitivity is about 4 and 40 ng for the drug and its metabolite, respectively. 10,11-Dihydrocarbamazepine is used as internal standard for the determinations, which have precisions of 2.2 and 4.2%, respectively. No derivatization is needed. The specificity of the method for carbamazepine is shown by the significant correlation (r = 0.99) between the results obtained by this method and by mass fragmentography for the drug in plasma of patients.
Similar articles
-
Clinical pharmacokinetics and pharmacological effects of carbamazepine and carbamazepine-10,11-epoxide. An update.Clin Pharmacokinet. 1986 May-Jun;11(3):177-98. doi: 10.2165/00003088-198611030-00001. Clin Pharmacokinet. 1986. PMID: 3524954 Review.
-
Measurement of carbamazepine and its epoxide metabolite by high-performance liquid chromatography, and a comparison of assay techniques for the analysis of carbamazepine.Clin Chem. 1977 Dec;23(12):2283-7. Clin Chem. 1977. PMID: 336243
-
Competitive nephelometric immunoassay of carbamazepine and its epoxide metabolite in patient blood plasma.J Pharmacobiodyn. 1981 Jan;4(1):77-83. doi: 10.1248/bpb1978.4.77. J Pharmacobiodyn. 1981. PMID: 7277195
-
Analysis of carbamazepine and its active metabolite, carbamazepine-10,11-epoxide, in human plasma using high-performance liquid chromatography.Anal Bioanal Chem. 2006 Nov;386(6):1931-6. doi: 10.1007/s00216-006-0724-7. Epub 2006 Sep 21. Anal Bioanal Chem. 2006. PMID: 17019579
-
Plasma levels of carbamazepine and carbamazepine-10,11-epoxide during treatment of epilepsy.Eur J Clin Pharmacol. 1976 Mar 22;09(5-6):417-21. doi: 10.1007/BF00606558. Eur J Clin Pharmacol. 1976. PMID: 971704
Cited by
-
Clinical pharmacokinetics of carbamazepine.Clin Pharmacokinet. 1978 Mar-Apr;3(2):128-43. doi: 10.2165/00003088-197803020-00003. Clin Pharmacokinet. 1978. PMID: 346287 Review.
-
A prospective randomised trial on the effect of monitoring plasma anticonvulsant levels in epilepsy.J Neurol. 1981;224(3):193-201. doi: 10.1007/BF00313281. J Neurol. 1981. PMID: 6162015 Clinical Trial.
-
Clinical pharmacokinetics in infants and children.Clin Pharmacokinet. 1976;1(1):2-24. doi: 10.2165/00003088-197601010-00002. Clin Pharmacokinet. 1976. PMID: 1017153
-
Plasma level monitoring of anticonvulsants.Clin Pharmacokinet. 1976;1(1):52-66. doi: 10.2165/00003088-197601010-00005. Clin Pharmacokinet. 1976. PMID: 797492 Review.
-
Clinical pharmacokinetics and pharmacological effects of carbamazepine and carbamazepine-10,11-epoxide. An update.Clin Pharmacokinet. 1986 May-Jun;11(3):177-98. doi: 10.2165/00003088-198611030-00001. Clin Pharmacokinet. 1986. PMID: 3524954 Review.