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. 2001 Mar;13(3):502-5.
doi: 10.1006/nimg.2000.0708.

Functional MRI activation of individual interictal epileptiform spikes

K Krakow  1 , D Messina, L Lemieux, J S Duncan, D R Fish
Affiliations

Functional MRI activation of individual interictal epileptiform spikes

K Krakow et al. Neuroimage. 2001 Mar.

Abstract

We used spike-triggered functional MRI in a patient with localization-related epilepsy to determine whether individual (as opposed to averaged) focal interictal epileptiform discharges (spikes) were associated with hemodynamic changes detectable with blood oxygen level-dependent functional MRI (fMRI). It was found that 15 of 43 spikes (34.9%) were associated with significant focal fMRI activation. Single event-related fMRI of interictal spikes is feasible in selected patients, giving complementary information to that provided by averaged fMRI data.

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