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. 2001 Jan;21(1):35-9.
doi: 10.1053/ejvs.2000.1264.

Ischaemia/reperfusion contributes to colonic injury following experimental aortic surgery

P U Reber  1 , M Peter, A G Patel, E Stauffer, G Printzen, D Mettler, H Hakki, H W Kniemeyer
Affiliations
Free article

Ischaemia/reperfusion contributes to colonic injury following experimental aortic surgery

P U Reber et al. Eur J Vasc Endovasc Surg. 2001 Jan.
Free article

Abstract

Objectives: ischaemia of the colon is an important complication of abdominal aortic aneurysm (AAA) repair. The aim of this animal study was to investigate the effect of sequential ischaemia and reperfusion on sigmoid mucosal pO2 and its association with local ET-1 release.

Material and methods: twelve pigs underwent colonic ischaemia followed by complete reperfusion. Six other animals were sham controls. A Clark-type microcatheter was used for continuous mucosal pO2 measurements. Serial systemic and inferior mesenteric vein blood samples were obtained for determination of ET-1 concentration. Neutrophil extravasation was assessed by tissue myeloperoxidase (MPO) activity.

Results: arterial occlusion was associated with a gradual decrease of mucosal pO2 and local release of ET-1. After restoration of blood flow, mucosal pO2 returned to near baseline values, whereas ET-1 reached its maximum concentration during the reperfusion period. MPO activity was significantly increased.

Conclusions: colonic ischaemia and reperfusion causes neutrophil extravasation and local ET-1.

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Comment in

  • Ischaemia/reperfusion.
    Kotsis TE, Dimakakos PB. Kotsis TE, et al. Eur J Vasc Endovasc Surg. 2001 Aug;22(2):186-7. doi: 10.1053/ejvs.2001.1427. Eur J Vasc Endovasc Surg. 2001. PMID: 11472058 No abstract available.

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