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. 2001 Feb 13;56(3):415-8.
doi: 10.1212/wnl.56.3.415.

Clinical trials in HIV-associated cognitive impairment: cognitive and functional outcomes

G Schifitto  1 , K Kieburtz, M P McDermott, J McArthur, K Marder, N Sacktor, D Palumbo, O Selnes, Y Stern, L Epstein, S Albert
Affiliations

Clinical trials in HIV-associated cognitive impairment: cognitive and functional outcomes

G Schifitto et al. Neurology. .

Abstract

Cognitive and functional outcomes are of primary interest in the design of efficacy trials in HIV-associated cognitive impairment. In a longitudinal cohort study, weak associations were found between measures of cognitive performance and commonly used measures of daily functioning (mostly self-report measures) in HIV-infected individuals. Modifications of current functional scales or new functional instruments are needed to assess the clinical relevance of cognitive changes in clinical trials of HIV-associated cognitive impairment.

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