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. 2001 Feb;138(2):244-9.
doi: 10.1067/mpd.2001.111274.

First-phase insulin release during the intravenous glucose tolerance test as a risk factor for type 1 diabetes

H P Chase  1 , D D Cuthbertson, L M Dolan, F Kaufman, J P Krischer, D A Schatz, N H White, D M Wilson, J Wolfsdorf
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First-phase insulin release during the intravenous glucose tolerance test as a risk factor for type 1 diabetes

H P Chase et al. J Pediatr. 2001 Feb.

Abstract

Objective: To determine the relationship between first-phase (1 minute + 3 minutes) insulin production during the intravenous glucose tolerance test (IV-GTT) and risk factors for developing type 1 diabetes.

Study design: Relatives of persons with type 1 diabetes (n = 59,600) were screened for islet cell antibodies (ICAs). Subjects who had positive screening results underwent IV-GTT (> or =2 times), repeat ICA screening, insulin autoantibody (IAA) screening twice, and an oral glucose tolerance test.

Results: Of the 59,600 subjects in the study, 2199 (3.69%) had positive findings on initial ICA test. IV-GTTs were performed in 1622 subjects, with children <8 years having the lowest first-phase insulin release (FPIR) and subjects 8 to 20 years of age having the highest FPIR. The FPIR was lower for subjects with a confirmed positive ICA test result or a positive IAA test result, subjects with higher titers of ICA or IAA, and subjects who had an abnormal (impaired or diabetic) oral glucose tolerance test result.

Conclusion: FPIR in the IV-GTT correlates strongly with risk factors for development of type 1 diabetes.

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