Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Apr;15(4):1024-8.
doi: 10.1128/JVI.15.4.1024-1028.1975.

Novel rII duplications in bacteriophage T4

F G Rothman, A R Robbins, D Lackey

Novel rII duplications in bacteriophage T4

F G Rothman et al. J Virol. 1975 Apr.

Abstract

The properties of two rII complementation heterozygotes (D5B and D7A) of bacteriophage T4 are described. These strains are characterized by their stability, each forming less than 10-3 r segregants among their viable progeny, and by their segregation of only one of the two parental types. No increase in r progeny was found on crossing D7A or D5B with T4r+, indicating that the duplications in these strains are not separated by an essential region of the phage genome. Both D5B and D7A from h-2+/h-4+ heterozygotes at frequencies similar to T4r+, suggesting that the duplicated regions in these strains are short. The progeny of these h-2+/h-4+ heterozygotes retain heterozygosity for rII but not for h: therefore, D5B and D7A are not stabilized terminal redundancy complementation heterozygotes. We conclude that D5B and D7A contain very short tandem duplications and we present structures consistent with the observed characteristics of these phages.

PubMed Disclaimer

References

    1. Genetics. 1965 Sep;52(3):683-93 - PubMed
    1. Proc Natl Acad Sci U S A. 1962 Jul 15;48:1114-21 - PubMed
    1. J Mol Biol. 1962 Apr;4:288-92 - PubMed
    1. Nature. 1961 Dec 30;192:1227-32 - PubMed
    1. Proc Natl Acad Sci U S A. 1967 Feb;57(2):292-5 - PubMed

LinkOut - more resources