Comment
doi: 10.1038/84728.
Soundbites
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- PMID: 11175770
- DOI: 10.1038/84728
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Comment
Soundbites
Nat Genet.
2001 Feb.
Abstract
Dentinogenesis imperfecta (DGI) is characterized by discolored teeth with an opalescent sheen and dentin that fails to support enamel, causing it to easily chip. Two new studies show that DGI is associated with mutations in DSPP, a gene encoding dentin sialophosphoprotein that is processed into two proteins: dentin sialoprotein (DSP) and dentin phosphoprotein (DPP). These are key components of the dentin extracellular matrix (DECM). Notably, missense mutations in DSPP are also associated with progressive hearing loss.
Comment on
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DSPP mutation in dentinogenesis imperfecta Shields type II.Nat Genet. 2001 Feb;27(2):151-2. doi: 10.1038/84765. Nat Genet. 2001. PMID: 11175779
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Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP.Nat Genet. 2001 Feb;27(2):201-4. doi: 10.1038/84848. Nat Genet. 2001. PMID: 11175790
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