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. 2001 Feb;27(2):156-8.
doi: 10.1038/84777.

Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats

M Pravenec  1 , V Landa, V Zidek, A Musilova, V Kren, L Kazdova, T J Aitman, A M Glazier, A Ibrahimi, N A Abumrad, N Qi, J M Wang, E M St Lezin, T W Kurtz
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Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats

M Pravenec et al. Nat Genet. 2001 Feb.

Abstract

Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension.

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