Comment on

• VEGF-D promotes the metastatic spread of tumor cells via the lymphatics.

  Stacker SA, Caesar C, Baldwin ME, Thornton GE, Williams RA, Prevo R, Jackson DG, Nishikawa S, Kubo H, Achen MG. Stacker SA, et al. Nat Med. 2001 Feb;7(2):186-91. doi: 10.1038/84635. Nat Med. 2001. PMID: 11175849
• Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis.

  Skobe M, Hawighorst T, Jackson DG, Prevo R, Janes L, Velasco P, Riccardi L, Alitalo K, Claffey K, Detmar M. Skobe M, et al. Nat Med. 2001 Feb;7(2):192-8. doi: 10.1038/84643. Nat Med. 2001. PMID: 11175850
• Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.

  Mäkinen T, Jussila L, Veikkola T, Karpanen T, Kettunen MI, Pulkkanen KJ, Kauppinen R, Jackson DG, Kubo H, Nishikawa S, Ylä-Herttuala S, Alitalo K. Mäkinen T, et al. Nat Med. 2001 Feb;7(2):199-205. doi: 10.1038/84651. Nat Med. 2001. PMID: 11175851