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Review
. 2001;3(2):98-101.
doi: 10.1186/ar146. Epub 2000 Dec 15.

The risk of upper gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combinations of these agents

L A Garcia Rodríguez  1 , S Hernández-Díaz
Affiliations
Review

The risk of upper gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combinations of these agents

L A Garcia Rodríguez et al. Arthritis Res. 2001.

Abstract

Most anti-inflammatory drugs have been associated with an increased risk of serious upper gastrointestinal complications. Epidemiological studies have estimated the magnitude of the risk for specific anti-inflammatory drugs. The risk of upper gastrointestinal tract bleeding or perforation increases around twofold with use of oral steroids or low dose aspirin, and increases around fourfold with use of nonaspirin nonsteroidal anti-inflammatory drugs. Acetaminophen at daily doses of 2000 mg and higher has also been associated with an increased risk. Overall, the risk is dose dependent and is greater with more than one anti-inflammatory drug taken simultaneously. Hence, whenever possible, anti-inflammatory drugs should be given in monotherapy and at the lowest effective dose in order to reduce the risk of serious upper gastrointestinal complications.

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References

    1. Piper JM, Ray WA, Daugherty JR, Griffin MR. Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Internal Med. 1991;114:735–740. - PubMed
    1. Holvoet J, Terriere L, Van Hee W, Verbist L, Fierens E, Hautekeete M. Relation of upper gastrointestinal bleeding to non-steroidal anti-inflammatory drugs and aspirin: a case-control study. Gut. 1991;32:730–734. - PMC - PubMed
    1. Keating J. Anti-inflammatory drugs and emergency surgery for peptic ulcers in the Waikato. NZ Med J. 1992;105:127–129. - PubMed
    1. Hallas J, Lauritsen J, Dalsgard Villadsen H, Freng Gram L. Non-steroidal anti-inflammatory drugs and upper gastrointestinal bleeding, identifying high-risk groups by excess risk estimates. Scand J Gastroenterol. 1995;30:438–444. - PubMed
    1. Pérez-Gutthann S, García Rodríguez LA, Raiford DS. Individual nonsteroidal anti-inflammatory drugs and other risk factors for upper gastrointestinal bleeding and perforation. Epidemiology. 1997;8:18–24. - PubMed

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