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Review
. 2000;1(2):REVIEWS0002.
doi: 10.1186/gb-2000-1-2-reviews0002. Epub 2000 Aug 4.

The sequence of human chromosome 21 and implications for research into Down syndrome

K Gardiner  1 , M Davisson
Affiliations
Review

The sequence of human chromosome 21 and implications for research into Down syndrome

K Gardiner et al. Genome Biol. 2000.

Abstract

The recent completion of the DNA sequence of human chromosome 21 has provided the first look at the 225 genes that are candidates for involvement in Down syndrome (trisomy 21). A broad functional classification of these genes, their expression data and evolutionary conservation, and comparison with the gene content of the major mouse models of Down syndrome, suggest how the chromosome sequence may help in understanding the complex Down syndrome phenotype.

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Figures

Figure 1
Figure 1
The regions of human chromosome 21 that are syntenic with mouse chromosomes are indicated on the left; those that are trisomic in the major mouse models are indicated on the right.
See this image and copyright information in PMC

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