Review
doi: 10.1517/13543784.10.2.343.
ABT-773: a new ketolide antibiotic
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- PMID: 11178346
- DOI: 10.1517/13543784.10.2.343
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Review
ABT-773: a new ketolide antibiotic
Expert Opin Investig Drugs.
2001 Feb.
Abstract
ABT-773 is a new semisynthetic derivative of erythromycin A, the ketolide class of broad spectrum antibacterial agents, in Phase II development by Abbott. With good broad spectrum activity against Gram-positive, some Gram-negative organisms and intracellular bacteria, ABT-773 is being developed as a respiratory agent. Structural changes in the ketolide class agents such as ABT-773 provides expanded activity in vitro against macrolide-resistant strains of Streptococcus pneumoniae and improved activity against MLS(B) (macrolide-lincosamide-streptogramin) constitutive expressing streptococci.
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