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Review
. 2001 Feb;120(3):607-21.
doi: 10.1053/gast.2001.22427.

Emerging concepts in gastrointestinal aspects of HIV-1 pathogenesis and management

E N Janoff  1 , P D Smith
Affiliations
Review

Emerging concepts in gastrointestinal aspects of HIV-1 pathogenesis and management

E N Janoff et al. Gastroenterology. 2001 Feb.

Abstract

GASTROENTROLOGY 2001;120:607-621

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Figures

Fig. 1
Fig. 1
HIV-1 entry in the gastrointestinal mucosa. Potential sites for HIV-1 entry include (1) disrupted epithelium caused by trauma or infection, (2) M cells, (3) dendritic cells, and (4) epithelial cells. Modified and reprinted with permission.
Fig. 2
Fig. 2
Schematic representation of HIV-1 translocation across the intestinal epithelium. Although both lymphocyte-tropic and macrophage-tropic HIV-1 are inoculated onto the mucosa, CCR5-mediated endocytosis, possibly in association with GalCer, initiates the transcytosis of macrophage-tropic virus from the apical surface of the epithelial cell to the basal surface. Released macrophage-tropic HIV-1 then infects CCR5+ lamina propria lymphocytes but not HIV-1. During early infection, virus replicates predominantly, if not exclusively, in lamina propria lymphocytes.
Fig. 3
Fig. 3
Effect of HAART on rates of major opportunistic infections in the populations. The pre-HAART and post-HAART dates are (A) 1995 and 1997, respectively, and (B) 1994 and 1998, respectively.
See this image and copyright information in PMC

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