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Case Reports
. 2001 Mar;70(3):382-5.
doi: 10.1136/jnnp.70.3.382.

Scleroderma "en coup de sabre": pathological evidence of intracerebral inflammation

J Stone  1 , A J Franks, J A Guthrie, M H Johnson
Affiliations
Case Reports

Scleroderma "en coup de sabre": pathological evidence of intracerebral inflammation

J Stone et al. J Neurol Neurosurg Psychiatry. 2001 Mar.

Abstract

Linear scleroderma "en coup de sabre" (LScs) is associated with neurological complications, the pathogenesis of which is uncertain. A 27 year old woman is reported on who developed epilepsy and focal neurological signs in association with LScs. Brain MRI demonstrated predominantly ipsilateral relapsing and remitting grey and white matter lesions. Analysis of CSF and pathology obtained at brain biopsy provides evidence of an inflammatory process which may be amenable to immunosuppressive treatment.

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