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Review
. 2001 Jan;8(1):1-7.
doi: 10.1016/s1074-5521(00)00058-2.

Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA

D A Braasch  1 , D R Corey
Affiliations
Review

Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA

D A Braasch et al. Chem Biol. 2001 Jan.

Abstract

Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2'-oxygen and the 4'-carbon. This conformation restriction increases binding affinity for complementarity sequences and provides an exciting new chemical approach for the control of gene expression and optimization of microarrays.

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