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. 2001 Apr;24(4):391-8.
doi: 10.1016/S0893-133X(00)00196-2.

Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice

M F O'Neill  1 , M W Conway
Affiliations
Free article

Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice

M F O'Neill et al. Neuropsychopharmacology. 2001 Apr.
Free article

Abstract

The purpose of this study was to further examine the effect of activation of 5-HT(1A) and 5-HT(1B) receptors in the forced swim test in mice and to determine if activation of these receptors played a role in the mediation of the effects of the tricyclic antidepressant imipramine. The 5-HT(1A) agonist 8-OH-DPAT decreased immobility in the forced swim test in mice as previously described. Both the selective 5-HT(1B) agonist anpirtoline (1.25-5 mg/kg) and mixed 5-HT(1A/B) agonist RU24969 (0.6-2.5 mg/kg) significantly increased time spent swimming in the FST.

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