[Change in the protein spectrum of the erythrocytic membranes in certain anemias]
[Article in
Russian]
- PMID: 1119119
Item in Clipboard
[Change in the protein spectrum of the erythrocytic membranes in certain anemias]
[Article in
Russian]
Vopr Med Khim.
1975 Jan-Feb.
Abstract
Proteins of human erythrocyte membranes were studied in normal state and in different anaemias. After solubilization of cell "shadows" in phenol-urea-acetic acid-water system in membranes there were found, by means of polyacrylamide gel disc electrophoresis, 20 protein fractions with molecular weight from 48000 to 225000; seven of them glycoproteins. In 9 cases out of 36 a complete or partial disappearance of a glycoprotein component with molecular weight of 170000 was observed in erythrocyte membranes from patients with inherited spherocytosis and Markiafava--Mikely disease.
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