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. 1975;28(3):200-6.
doi: 10.1111/j.1423-0410.1975.tb02758.x.

Dissociation of MNSs antigens using sodium deoxycholate fraction of erythrocyte membranes

S H Zuckerman, S D Douglas, J Nusbacher

Dissociation of MNSs antigens using sodium deoxycholate fraction of erythrocyte membranes

S H Zuckerman et al. Vox Sang. 1975.

Abstract

A dissociation of the MNSs blood group system has been demonstrated by sodium deoxycholate fractionation of erythrocyte membrane preparations. The MN antigens were localized in a fraction that sedimented at 30,000 g while the Ss antigens remained soluble after 100,000 g centrifugation for donors who were heterozygous at the MN locus. In contrast, fractions derived from erythrocytes of 'homozygous' M or N donors showed M or N activity in both the 30,000 g pellet and 100,000 g supernatant and Ss remained in the 100,000 g supernatant.

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