Review
doi: 10.1111/j.1749-6632.2000.tb05575.x.
Oxidative metabolism
Affiliations
- PMID: 11193793
- DOI: 10.1111/j.1749-6632.2000.tb05575.x
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Review
Oxidative metabolism
Ann N Y Acad Sci.
2000.
Abstract
There is a large body of evidence showing both metabolic defects and oxidative damage in Alzheimer's disease. Studies of cybrid cell lines show reduced cytochrome oxidase. There is also substantial evidence for a defect in alpha-ketoglutarate dehydrogenase. It is therefore possible that therapeutic strategies to improve brain metabolism or ameliorate oxidative damage might be useful in treating Alzheimer's disease.
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