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Clinical Trial
. 2000 Nov-Dec;19(6):797-800.
doi: 10.1080/07315724.2000.10718080.

Feeding tolerance in preterm infants: randomized trial of bolus and continuous feeding

S Dollberg  1 , J Kuint, R Mazkereth, F B Mimouni
Affiliations
Clinical Trial

Feeding tolerance in preterm infants: randomized trial of bolus and continuous feeding

S Dollberg et al. J Am Coll Nutr. 2000 Nov-Dec.

Abstract

Objective: To test the hypothesis that continuous gastric infusion (CGI) is better tolerated than intermittent gastric bolus (IGB) in small very low birth weight (VLBW) infants.

Design: Two-center, prospective, randomized, unmasked clinical trial.

Patients: 28 VLBW infants (birth weight <1250 g). A strict feeding protocol was followed.

Intervention: Patients were randomized to IGB or CGI.

Main outcome measures: Time to reach full feeds (160 cc/kg/d)(by design and real), daily weight, caloric intake, residual gastric volume and type of feeding (formula vs. human milk vs. both).

Results: Five infants failed to complete the study because of death (n = 4) or protocol violation (n = 1). The two groups did not differ by birth weight or gestational age; infants fed via IGB reached full feeds earlier (p = 0.03) and had less delay in reaching full feeds than infants fed via CGI.

Conclusion: Contrary to our hypothesis, gravity IGB is more effective than CGI in improving feeding tolerance in small VLBW infants.

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