[The role of histamine in vagal and gastrin effects on the secretory function of the rat stomach]

Abstract

In lumen-perfused stomachs of anaesthetized rat, acid and bicarbonate types of secretion were estimated on the basis of pH/PCO2 measurements. The data obtained reveal that, in anaesthetised rats, pentagastrin and cholinergic input affect acid secretion mainly indirectly via histamine release. Vagal effects on pepsinogen output are mediated partially via indirect histamine pathways. The direct action of pentagastrin, however, predominates. Bicarbonate production is subjected to cholinergic control alone.