Comparative Study
doi: 10.1097/00000542-197504000-00010.
Metabolism in vitro of enflurane, isoflurane, and methoxyflurane
- PMID: 1119709
- DOI: 10.1097/00000542-197504000-00010
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Comparative Study
Metabolism in vitro of enflurane, isoflurane, and methoxyflurane
Anesthesiology.
1975 Apr.
Abstract
Specific activities of enflurane, isoflurane, and methoxyflurane defluorinases were measured in microsomes prepared from the livers of Fischer 344 rats; the ratio of these activities was 23:3:1. Pretreatment with phenobarbital significantly increased the defluorinase activities of all three agents. Factors that influence anesthetic drug metabolism are discussed; tissue solubility is considered to be the most important.
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