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Review
. 2000 Dec;72(4):408-11.

A chemokine, SDF-1/PBSF, and its receptor, CXC chemokine receptor 4, as mediators of hematopoiesis

T Nagasawa  1
Affiliations
  • PMID: 11197205
Review

A chemokine, SDF-1/PBSF, and its receptor, CXC chemokine receptor 4, as mediators of hematopoiesis

T Nagasawa. Int J Hematol. 2000 Dec.

Abstract

A chemokine, stromal cell-derived factor/pre-B-cell growth-stimulating factor (SDF-1/PBSF), and its primary physiologic receptor, CXC chemokine receptor 4 (CXCR4), are essential for B-lymphocyte production and colonization of bone marrow by myeloid lineage progenitors during embryogenesis. Moreover, CXCR4 is an autonomous cell essential for long-term lymphoid and myeloid reconstitution in adult bone marrow. Upregulation of CXCR4 expression may be useful for improving engraftment of repopulating stem cells in clinical transplantation.

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