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. 2001 Jan 6;357(9249):42-3.
doi: 10.1016/s0140-6736(00)03573-x.

Multidrug-resistance protein 1 in focal cortical dysplasia

S M Sisodiya, W R Lin, M V Squier, M Thom

Multidrug-resistance protein 1 in focal cortical dysplasia

S M Sisodiya et al. Lancet. .

Abstract

Drug resistance in epilepsy is poorly understood. We used routine immunohistochemistry to assess overexpression of a multidrug-resistance protein in dysplastic neurons, glia, and around vessels in surgically resected epileptogenic human brain tissue. We showed non-tumoral overexpression of this multidrug-resistance protein, which might contribute to drug resistance in epilepsy caused by focal cortical dysplasia.

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